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. 2018 Feb 13;293(14):5295–5306. doi: 10.1074/jbc.RA118.001593

Figure 6.

Figure 6.

Involvement of cannabinoid and PPAR receptors in mPGES-1 induction. A, induction of mPGES-1 in WT and FABP5 KO mouse hind paws after injection with carrageenan. Mice were administered vehicle, the cannabinoid receptor 1 and 2 antagonists AM251 and AM630 (3 mg/kg, i.p.), or the PPARα antagonist GW6471 (4 mg/kg, i.p.). Paws were harvested 24 h after carrageenan injection. B, quantification of mPGES-1/GAPDH band intensities of Western blots described in A and C. *, p < 0.05 versus carrageenan-injected WT mice (n = 6–8). C, induction of mPGES-1 in paws of WT and FABP5 KO mice treated with vehicle or the PPARγ antagonist GW9662 (2 mg/kg, i.p.). D, PGE2 levels in hind paws of WT and FABP5 KO mice administered AM251/AM630, GW6471, or GW9662. PGE2 levels were quantified at baseline and 24 h after carrageenan injection. *, p < 0.05; **, p < 0.01 versus carrageenan-injected WT mice (n = 6). Error bars represent S.E.