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. 2018 Apr 3;11:649–659. doi: 10.2147/JPR.S153544

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Knockdown of Shh in spinal cord prevents the reduction of chronic morphine treatment-induced MPE%.

Notes: (A) Effects of Shh targeting siRNA (1 μg i.t., daily for 3 consecutive days) on the expression of Shh in naïve mice (n=6 in each group). Whole spinal cord tissues were collected 2 hours after the last injection. (B) Knockdown of Shh significantly prevented the reduction of chronic morphine treatment-induced MPE% (n=10 in each group). (C) Effects of Shh targeting siRNA (1 μg i.t., daily for 3 consecutive days) on the expression of Shh in morphine-treated mice (n=6 in each group). Whole spinal cord tissues were collected at day 4 after the first morphine injection. *P<0.05, **P<0.01 versus con-siRNA+Mor group.

Abbreviations: MPE%, percentage of maximal possible effect; siRNA, small interfering RNA; i.t., intrathecally; Mor, morphine; con-siRNA, control-siRNA.