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. 2018 Apr 3;11:649–659. doi: 10.2147/JPR.S153544

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© 2018 Liu et al. This work is published and licensed by Dove Medical Press Limited

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Shh signaling inhibition with cyclopamine suppressed morphine treatment-induced upregulation of c-fos and CGRP in the spinal cord of mice.

Notes: (A) Examples of immunofluorescence images and data summary (n=6 in each group) showing the expression of c-fos and CGRP in the dorsal horn of the spinal cord. Magnification: 200×. (B) Examples of Western blot analysis and data summary (n=6 in each group) showing the expression of c-fos and CGRP in the spinal cord. Samples were collected at day 4 after the first morphine injection. Cyclopamine (10 mg/kg, i.p.) was coadministrated with morphine on days 1, 2, and 3. *P<0.05, **P<0.01 versus sham group. ^##P<0.01 versus Mor group.

Abbreviations: i.p., intraperitoneally; Mor, morphine; CLP, cyclopamine.