Table 1. Blood concentrations of rapamycin and metformin at sacrifice.

Group	Rapamycin [ng/mL]	p value: eRapa vs eRapa+Met	Metformin [µg/mL]	p value: Met vs eRapa+Met
Male
eRapa	38 ± 7		-
Met	-		2.1 ± 0.3
eRapa+Met	41 ± 7	0.79	1.3 ± 0.2	0.04
Female
eRapa	43 ± 8		-
Met	-		3.9 ± 1.0
eRapa+Met	27 ± 4	0.07	1.3 ± 0.2	0.07

p value presented is for t test comparing values of indicated groups. Dash indicates levels of this drug in indicated group fall below level of detection. Control groups for both males and females have undetectable levels of both rapamycin and metformin.