Table 1. Basic characteristics of cohorts included in the analyses.
| Cohort | Sample | Number | Age (SD), | Birth dates | Quantitative markers | Risk outcomes |
| size | of visits | years | (range) | |||
| Markers: BG, BMI, CRP, creatinine, DBP, FVC, HC, HDL-C, HR, SBP, TC, TG | ||||||
| Risk outcomes: AD, AF, cancer, CHD, DM, death, HF, stroke | ||||||
| ARIC | 9,612 | 4 | 54.3 (5.7) | 1921-1944 | All | All except AD |
| CHS | 3,182 | 10 | 72.4 (5.4) | 1885-1925 | All | All |
| FHS | 8,628 | 28* | 37.8 (9.3) | 1885-1980 | All | All |
| MESA | 2,527 | 5 | 64.3 (10.2) | 1917-1957 | All | All except cancer and AD |
| HRS | 9,482 | 2 | 58.2 (9.1) | 1905-1974 | All except creatinine, FVC, HC, HR, and TG | All except AF |
Cohort: Atherosclerosis Risk in Communities Study (ARIC); Cardiovascular Health Study (CHS); Framingham Heart Study (FHS), the Multi-Ethnic Study of Atherosclerosis (MESA), and Health and Retirement Study (HRS).
Age is given at baseline; standard deviation (SD).
*Number of visits in the FHS original cohort, offspring and 3rd generation cohort are 28, 8, and 2, respectively.
Quantitative markers: blood glucose (BG); body mass index (BMI); C-reactive protein (CRP); creatinine; diastolic blood pressure (DBP); forced vital capacity (FVC); heart rate (HR); hematocrit (HC); high-density lipoprotein cholesterol (HDL-C); systolic blood pressure (SBP); total cholesterol (TC); and triglycerides (TG).
Risk outcomes: Alzheimer’s disease and related dementias (AD), atrial fibrillation (AF); cancer; coronary heart disease (CHD); diabetes mellitus (DM); death; heart failure (HF); and stroke.
Additional details are provided in Supplementary Table 1.