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CerS2 overexpression induces increased insulin resistance in AC16 cardiomyocytes. A, B) CerS2 overexpression caused decreased insulin-induced phosphorylation of AKT compared with vehicle plasmid controls. C) Although CerS2 overexpression had no effect on basal glucose uptake, it disrupted insulin-dependent glucose uptake. Student’s t test (n = 3–6). *P < 0.05, **P < 0.01 compared with control (ctrl).
