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. 2018 Jan 4;32(3):1403–1416. doi: 10.1096/fj.201700300R

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Figure 8. — Inhibition of mitophagy exacerbates apoptosis induced by a VLC mitochondrially targeted ceramide analog in H9c2 cardiomyocytes. A) Positively charged pyridinium ceramides were used of medium (LCL29), long (LCL88), and very long (LCL30) acyl-chain lengths. B, C) LCL30 increased localization of P62 to the mitochondrially enriched fraction. D) Mitochondrial reserve capacity was significantly decreased after LCL29 and LCL30 treatment. E) Only LCL30 reduced cardiomyocyte viability. G) PARP cleavage was induced by addition of LCL30. F–H) Increased PARP cleavage occurred after treatment with LCL-30 and drp-1 mitochondrial division inhibitor mdivi-1, which resulted in greater cardiomyocyte (H9c2) apoptosis. One-way ANOVA. *P < 0.05 compared with control (ctrl) (n = 3).