TABLE 2.
Day 16 ceramide mouse heart high-fat diet lipidomics (pM/mg)
| N-acyl chain | Control | Control + myriocin | Milk-fat diet | Milk-fat diet + myriocin |
|---|---|---|---|---|
| Total | 0.5 ± 0.3 | 1.5 ± 0.5 | 4.2*** ± 0.6 | 2.4 ± 0.5 |
| C14 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C16 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C18 | 0.1 ± 0.1 | 0.4 ± 0.1 | 1.4*** ± 0.3 | 1.0** ± 0.2 |
| C18:1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C20 | 0.3 ± 0.1 | 0.7 ± 0.2 | 1.1** ± 0.2 | 0.7 ± 0.1 |
| C20:1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C22 | 0.0 ± 0.0 | 0.2 ± 0.2 | 1.3*** ± 0.2 | 0.4** ± 0.2 |
| C22:1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C24 | 0.0 ± 0.0 | 0.2 ± 0.1 | 0.5** ± 0.1 | 0.3 ± 0.1 |
| C24:1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C26 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
| C26:1 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 | 0.0 ± 0.0 |
Data are means ± SEM; n = 5 for all groups