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. 2018 Mar 30;4(1):e000564. doi: 10.1136/rmdopen-2017-000564

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Cumulative probability of time to achieve first sustained DAS28 (CRP) remission by conversion to ACPA seronegative status. The cumulative probability of the time to achieve sustained first DAS28 (CRP) remission over 12 months in all patients treated with abatacept+MTX or MTX alone who underwent conversion to ACPA seronegative status compared with those who remained ACPA seropositive was evaluated based on estimated Kaplan-Meier curves. DAS28 (CRP) values were measured at all study visits (screening, days 1, 15 and 29, and then every 28 days) over 12 months. Antibody titres were determined by ELISA at baseline and months 6 and 12. Baseline to month 6 and baseline to month 12 were carried out as separate analyses. ACPA, anti-citrullinated protein antibody; CRP, C-reactive protein; DAS28, Disease Activity Score in 28 joints; MTX, methotrexate.