Table 2.
Risk factors associated with healthcare-associated infections caused by carbapenem-resistant or -sensitive Acinetobacter baumannii in a neonatal intensive care unit in Egypt (N = 124)
| Risk factor | Univariate analysis, n (%) | Multivariate analysis | |||
|---|---|---|---|---|---|
| CRAB (n = 91) | CSAB (n = 33) | P value | aOR (95% CI) | P value | |
| Postnatal age in days | |||||
| <7 | 45 (49.5) | 18 (54.5) | 0.65 | ||
| ≥7 | 46 (50.5) | 15 (45.5) | 0.35 | ||
| Male gender | 39 (42.9) | 16 (48.5) | 0.78 | ||
| Prematurity | 54 (59.3) | 8 (24.2) | 0.03* | 25.3 (8.4–784.8) | <0.01* |
| LBW | 29 (31.9) | 10 (30.3) | 0.88 | ||
| PROM | 42 (46.2) | 5 (15.2) | 0.01* | ||
| PSAH | 17 (18.7) | 2 (6.1) | 0.03* | ||
| Median length of stay in the NICU prior to HAI (range) | 10 (6.4–15.2) | 4 (2.6–7.9) | 0.04* | ||
| Presence of an invasive device | |||||
| Umbilical catheter | 70 (76.9) | 11 (33.3) | 0.04* | ||
| PPCL | 10 (11) | 5 (15.2) | 0.85 | ||
| Urinary catheter | 66 (72.5) | 7 (21.2) | <0.01* | ||
| MV | 72 (79.1) | 9 (27.3) | <0.01* | 18.9 (3.5–1,135.1) | <0.01* |
| Previous antibiotic exposure | |||||
| Carbapenems | 55 (60.4) | 5 (15.2) | <0.01* | 124.7 (45.2–588.1) | <0.01* |
| Cephalosporins | 24 (26.4) | 6 (18.2) | 0.07 | ||
| Aminoglycosides | 42 (46.2) | 4 (12.1) | 0.02* | 22.6 (1.1–864.9) | 0.04* |
| Vancomycin | 30 (33) | 12 (36.4) | 0.79 | ||
| Median duration of antibiotic therapy before HAI in days (range) | 8 (5.7–10.4) | 2 (1.2–4.6) | <0.05* | ||
CRAB = carbapenem-resistant Acinetobacter baumannii; CSAB = carbapenem-sensitive A. baumannii; aOR = adjusted odds ratio; CI = confidence interval; LBW = low birth weight; PROM = premature rupture of the membranes; PSAH = previous stay in another hospital; NICU = neonatal intensive care unit; HAI = healthcare-associated infection; PPCL = peripheral percutaneous central line; MV = mechanical ventilator.
*
Considered statistically significant at P ≤0.05.