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. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: J Mol Cell Cardiol. 2018 Mar 2;117:36–48. doi: 10.1016/j.yjmcc.2018.02.016

Figure 3. tTG inhibition attenuates diastolic dysfunction in the pressure-overloaded myocardium.

Figure 3

A: Speckle tracking echocardiography demonstrated that in comparison to vehicle-treated pressure overloaded animals (V), mice treated with the tTG inhibitor (ERW) had higher systolic strain rate (SSR) after 28 days of TAC. The effects of the inhibitor were noted in male (C), but not in female animals (B). D: tTG inhibition preserved diastolic strain rate (DSR) after 28 days of TAC, suggesting attenuated diastolic dysfunction. E–F: The protective effects of the inhibitor were noted in both female and male animals (*p<0.05, **p<0.01, n=14–15/group; male: n=5–9/group; female: n=5–10/group).