Table 2. IgM and IgG ELISA results in patients grom various settings.
| Clinical condition and setting | Type of IgG ELISA | No. samples / patients tested | ELISA result (% samples) | ||||
|---|---|---|---|---|---|---|---|
| IgM+a | IgM+ onlyb | IgM+ and IgG+c | IgG+d | IgG+ onlye | |||
| Clinical Lassa fever suspicion and Lassa virus RT-PCR-positive on diagnostic specimen in endemic area (Nigeria) | RF | 270/270 | 31.1 | 5.2 | 25.9 | 33.7 | 7.8 |
| CD32 | 270/270 | 31.1 | 5.2 | 25.9 | 33.3 | 7.4 | |
| Follow-up specimens of Lassa virus RT-PCR-positive patients (Nigeria) | RF | 179/47 | 62.0 | 1.7 | 60.3 | 71.5 | 11.2 |
| CD32 | 179/47 | 62.0 | 3.4 | 58.7 | 69.8 | 11.2 | |
| Clinical Lassa fever suspicion and Lassa virus RT-PCR-negative in endemic area (Nigeria) | RF | 101/101 | 5.0f | 1.0 | 4.0f | 20.8 | 16.8 |
| CD32 | 101/101 | 5.0f | 1.0 | 4.0f | 23.8 | 19.8 | |
| Clinical VHF suspicion and Lassa virus RT-PCR-negative in non-endemic area (Ghana) | RF | 199/199 | 6.5g | 6.5 | 0 | 0 | 0 |
| CD32 | 100/100 | 7.0g | 7.0 | 0 | 0 | 0 | |
| Patients with various diseases in non-endemic area (Germany) | RF | 105/105 | 0 | 0 | 0 | 0 | 0 |
| CD32 | 100/100 | 0 | 0 | 0 | 0 | 0 | |
Abbreviations: ELISA enzyme-linked immunosorbent assay; RF, rheumatoid factor; VHF, viral hemorrhagic fever.
a Sample was IgM positive irrespective of IgG result.
b Sample was IgM positive and IgG negative.
c Sample was IgM positive and IgG positive.
d Sample was IgG positive irrespective of IgM result.
e Sample was IgG positive and IgM negative.
f All IgM and IgG positive samples also tested positive for IgM and IgG, respectively, in IFA.
g All IgM positive samples tested negative for IgM in IFA.