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. 2018 Apr 3;13:1945–1962. doi: 10.2147/IJN.S153763

Figure 9.

Figure 9

(A) Apoptosis assessment of cardiac cells in Sham, DM-8w, Curcumin, Curcumin/P, Curcumin+CaRS, Curcumin/P+CaRS, Curcumin+CaRI, and Curcumin/P+CaRI groups. (B) Apoptosis assessment of cardiac cell in Sham, DM-8w, Curcumin, Curcumin/P, Curcumin+PAG, Curcumin/P+PAG, Curcumin+CaRS+PAG, and Curcumin/ P+CaRS+PAG groups.

Notes: (A) Apoptosis in Sham group (a), DM-8w group (b), Curcumin group (c), Curcumin/P group (d), Curcumin+CaRS group (e), Curcumin/P+CaRS group (f), Curcumin+CaRI group (g), and Curcumin/P+CaRI group (h). The apoptosis in DM-8w group is higher than that in Sham group, and the apoptosis in Curcumin group, Curcumin+CaRS group, and Curcumin+CaRI group is lower than that in DM-8w group; the apoptosis in Curcumin/P group, Curcumin/P+CaRS group, and Curcumin/P+CaRI group is significantly lower than that in DM-8w group. (B) Apoptosis in Sham group (a), DM-8w group (b), Curcumin group (c), Curcumin/P group (d), Curcumin+PAG group (e), Curcumin/P+PAG group (f), Curcumin+CaRS+PAG group (g), and Curcumin/P+CaRS+PAG group (h). The apoptosis in DM-8w group is higher than that in Sham group, and the apoptosis in Curcumin group, Curcumin+PAG group, and Curcumin+CaRS+PAG group is lower than that in DM-8w group; the apoptosis in Curcumin/P group, Curcumin/P+PAG group, and Curcumin/P+CaRS+PAG group is significantly lower than that in DM-8w group. Magnification is ×100.

Abbreviations: CaSR, calcium sensing receptor; DM, diabetes mellitus; CaRS, calcium-sensing receptor stimulator; CaRI, calcium-sensing receptor inhibitor; P, poly(gamma-benzyl l-glutamate)-poly(ethylene glycol)-poly(gamma-benzyl l-glutamate); PAG, DL-propargylglycine.