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. 2018 Mar 23;24:239–250.

Table 1. Total cell count in RGCL and optical dissector parameters.

Groups name
  Control
n=6 IR
n=6 Bevacizumab
n=6
Mean Total Retinal Ggl Cell Count ± SEM
203.712±27.749
131.133±16.025
173.289±5.336
Dissector Particle Number
446
319
393
Section Thickness (µm)
20,5
19,5
19,7
Number of Sampled Sections
25,2
23
24
CE
0,05
0,05
0,05
CV 0,09 0,14 0,09

Mean total ganglion cell count ±SEM, mean dissector number, section thickness, number of sampled sections, coefficient of error (CE), and coefficient of variation (CV) of stereological analysis between subjected to ischemia/reperfusion and treatment groups in the rodents. The stastical difference between all the groups is significant ; between C and IR p<0.0001, C and BEV p<0.01 and IR and BEV p<0.01. The neurodegenerative effects of IR and the neuroprotective effects of BEV were examined by inducing 45 min of an ischemic insult and following a reperfusion of 48 h. There were 203.712±27.749 cells in the RGCL in the control group and 131.133±16.025in the IR group, showing a 36% decrease in living cells as a strong sign of neurodegeneration (p<0.0001). When we compared the cell numbers in the BEV group 173.289±5.336to the IR group 131.133±16.025we clearly saw there was a higher number of cells in the BEV group, and the difference was statistically significant (p<0.01). This is a strong clue that BEV has a neuroprotective effect in the event of ischemia.