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. 2018 Jan 5;32(4):2235–2245. doi: 10.1096/fj.201700459RR

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This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0) (http://creativecommons.org/licenses/by-nc/4.0/) which permits noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — GR signaling is necessary for successful fracture repair. Bending stiffness of fracture calli was analyzed by 3-point bending test (A). Healing frequency was assessed from µCT data sets (B). White proportion, healed; gray proportion, not healed. BMD (C), trabecular number (Tb.N, D), trabecular thickness (Tb.Th, E), and trabecular spacing (Tb.Sp, F) were determined in former osteotomy by µCT. Osteoblast number per bone perimeter (Ob.N/B.Pm, G), osteoblast surface per bone surface (Ob.S/BS, H), osteoclast number per bone perimeter (Oc.N/B.Pm, I), and osteoclast surface per bone surface (Oc.S/BS, J) were assessed in callus by histomorphometry. Data are presented as means ± sem; n = 7–9 per group. All data are derived from d 28 after surgery. *P ≤ 0.05.