TABLE 8.
Canonical pathways predicted to be activated by IPA for HMEEC exosome proteins
| Ingenuity canonical pathway | P | Ratio |
|---|---|---|
| Protein ubiquitination pathway | 1.2e−25 | 0.224 |
| tRNA charging | 1.2e−17 | 0.513 |
| EIF2 signaling | 3.9e−12 | 0.18 |
| Glycolysis I | 5.8e−8 | 0.44 |
| Caveolar-mediated endocytosis signaling | 2.5e−8 | 0.239 |
| Remodeling of epithelial adherens junctions | 9.4e−6 | 0.221 |
| Clathrin-mediated endocytosis signaling | 4.4e−6 | 0.132 |
| Actin cytoskeleton signaling | 2.8e−6 | 0.123 |
| Tight junction signaling | 5.1e−5 | 0.132 |
| Epithelial adherent junction signaling | 3.2e−5 | 0.137 |
| Cleavage and polyadenylation of pre-mRNA | 2.5e−5 | 0.5 |
The dataset of 883 exosome proteins was entered in IPA and a Core analysis was performed. EIF2, eukaryotic initiation factor 2.