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. 2018 Jan 5;32(4):1916–1932. doi: 10.1096/fj.201700826R

Figure 7.

Figure 7.

Inflammation and apoptosis are increased in mice with acute neuronal NF-κB inhibition. Expression of proinflammatory and apoptotic genes in the acute IKK2-DNCamk2a mouse model. Acute IKK2-DNCamk2a mice also exhibited prominent neuroinflammation and apoptosis induction 3 d after TBI, similar to chronic IKK2-DNCamk2a mice. This finding is indicated by qPCR analysis of the complement factor C3 (A); the astroglial marker Gfap (B); the acute phase protein Lcn2 (C); the inflammatory cytokine Il1b (D); the neuronal activity marker c-Fos (E); the proapoptotic genes Bax (F), Bad (G), and Bak (H); the antiapoptotic genes Bcl2 (I) and BclXL (J); and the stress response genes in the p53 pathway Atf3 (K) and p21 (L). Measured expression levels are presented relative to Hprt. Means ± sem (n = 3–6). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001 [not significant (ns), at 3 d after TBI, between the indicated groups, by 1-way ANOVA, followed by Bonferroni’s post hoc test].