Effect of tertiapinQ on persistent AF in isolated Langendorff-perfused hearts. A) APD at APD75 and APD50 at constant 2.5 Hz pacing in PLA, LA, and RA, before and after the application of 0.2 µM tertiapinQ (n = 4). B) Representative DF maps of the PLA, LA, and RA in baseline AF and 2 and 4 min after 0.1 µM tertiapinQ perfusion. After 4 min, the heart spontaneously reverted to a 0.8 Hz SR. C) Time course of the average DF in 4 hearts, 30 min before and after TertiapinQ perfusion. The black × marks indicate the time of spontaneous AF cardioversion in each of the hearts. D) Average maximum DF right before TertiapinQ application at baseline and immediately before AF termination. *P < 0.05, **P < 0.01.