Table 3.
Univariate analysis of risk factors of potentially damaging immunization delay of children 2–24 months followed by primary-care pediatricians.
| 2 m vaccines (n = 440) | 4m vaccines (n = 384) | 11 m vaccines (n = 209) | |||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| (PCV + DTaP-IPV Hib ± VHB) |
(PCV + DTaP-IPV-Hib ± VHB) |
(PCV + DTaP-IPV-Hib ± VHB) |
12 m vaccines (n = 170)(1st MMR + MenC) |
Global delay |
|||||||||||
| Variables | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p | OR | 95%CI | p |
| Children's characteristics | |||||||||||||||
| Male | 1.0 | 0.6–1.6 | 0.83 | 1.1 | 0.7–1.7 | 0.84 | 0.9 | 0.5–1.7 | 0.70 | 0.9 | 0.5–1.7 | 0.72 | 0.8 | 0.5–1.1 | 0.16 |
| Rank in the sibling ≥3 | 1.7 | 0.9–3.3 | 0.09 | 1.3 | 0.7–2.6 | 0.34 | 1.3 | 0.5–3.2 | 0.54 | 0.9 | 0.3–2.4 | 0.87 | 1.4 | 0.8–2.2 | 0.20 |
| Child attending day-care center | 0.7 | 0.4–1.2 | 0.14 | 0.7 | 0.4–1.1 | 0.10 | 1.2 | 0.6–2.5 | 0.55 | 1.6 | 0.8–3.2 | 0.16 | 1.5 | 1.0–2.2 | 0.03 |
| Prematurity < 37SA | 1.0 | 0.4–2.6 | 0.95 | 1.3 | 0.6–3.0 | 0.49 | 1.5 | 0.4–5.4 | 0.34 | 1.7 | 0.4–6.9 | 0.40 | 1.3 | 0.6–2.7 | 0.44 |
| PMH of severe infection | 1.9 | 0.6–6.1 | 0.23 | 2.1 | 0.7–6.3 | 0.15 | 5.1 | 1.1–26.9 | 0.02 | 4.6 | 0.5–104 | 0.13 | 3.9 | 1.2–14.5 | 0.01 |
| Chronic disease | 1.3 | 0.5–3.2 | 0.61 | 1.4 | 0.6–3.2 | 0.42 | 1.4 | 0.5–4.1 | 0.50 | 0.8 | 0.2–3.0 | 0.75 | 1.3 | 0.6–2.9 | 0.45 |
| Multidisciplinary management | 1.2 | 0.3–4.8 | 0.50 | 2.3 | 0.7–8.0 | 0.13 | 4.1 | 0.7–25.0 | 0.07 | 5.1 | 0.6–118 | 0.10 | 1.6 | 0.5–5.4 | 0.40 |
| Familiy's characteristics | |||||||||||||||
| Study of mother: higher education | 1.0 | 0.6–1.7 | 0.85 | 0.8 | 0.5–1.3 | 0.28 | 1.3 | 0.6–2.7 | 0.42 | 1.0 | 0.5–2.1 | 0.94 | 1.0 | 0.7–1.5 | 0.99 |
| Working mother | 1.5 | 0.8–3.0 | 0.19 | 2.2 | 1.2–4.2 | 0.008 | 1.7 | 0.6–4.8 | 0.24 | 2.0 | 0.7–10.0 | 0.14 | 2.0 | 1.1–3.3 | 0.01 |
| Isolated parents | 2.9 | 0.8–10.1 | 0.06 | 2.6 | 0.6–10.8 | 0.12 | 1.2 | 0.0–17.1 | 0.65 | 0.7 | 0.0–27.3 | 0.66 | 1.9 | 0.5–6.7 | 0.28 |
| Chronic disease of one parent | 0.6 | 0.3–1.2 | 0.12 | 0.5 | 0.3–1.0 | 0.03 | 0.9 | 0.4–2.0 | 0.73 | 0.7 | 0.3–1.5 | 0.32 | 0.7 | 0.4–1.2 | 0.13 |
| Vaccine related adverse event* | 0.7 | 0.1–3.6 | 0.50 | 0.6 | 0.1–2.9 | 0.36 | 7.3 | 0.7–189 | 0.08 | / | / | 0.19 | 0.9 | 0.3–2.8 | 0.77 |
| PMH of VPD* | 1.0 | 0.4–2.1 | 0.93 | 1.1 | 0.5–2.2 | 0.81 | 1.3 | 0.5–3.4 | 0.56 | 3.8 | 1.0–17.7 | 0.06 | 1.0 | 0.6–1.9 | 0.93 |
DTaP-IPV-Hib ± VHB-PCV: diphtheria-tetanus-acellular pertussis-inactivated polio vaccine-Haemophilus influenzae b ± hepatitis B vaccine-pneumococcal conjugate vaccine; MMR: Measles-Mumps-Rubella vaccine; MenC: meningococcal C vaccine; PMH: past medical history; VPD: vaccine preventable disease;
*
related to siblings, father, mother and great-parents.