Table 1.
Virus Titers (log10 PFU/mosquito) in Individual Mosquitoes Following Intrathoracic Inoculation.
| VSV-I |
V920 |
VSV-SFV |
||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PFU/mosquito (log10) |
PFU/mosquito (log10) |
PFU/mosquito (log10) |
||||||||||||||||
| Day Post Infection | Number of Positive Mosquitoes | A† | B | C | D | E | Number of Positive Mosquitoes | A | B | C | D | E | Number of Positive Mosquitoes | A | B | C | D | E |
| Culex quinquefasciatus titers post-IT inoculation | ||||||||||||||||||
| 0 | 4/5 | 2.2 | 1.7 | 2.3 | 0 | 2 | 4/5 | 2 | 2 | 2 | 2.2 | 0 | 0/3 | 0 | 0 | 0 | ||
| 1 | 2/5 | 0 | 0 | 3.9 | 4.1 | 0 | 4/4 | 1.4 | 1.4 | 2.4 | 1.7 | 0/3 | 0 | 0 | 0 | |||
| 2 | 4/4 | 4.4 | 4.4 | 4.3 | 5.1 | 0/4 | 0 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||
| 4 | 3/3 | 4.7 | 4.5 | 4.1 | 0/3 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||||
| 8 | 3/3 | 5.4 | 4.9 | 4.7 | 1/3 | 0 | 0 | 2.5 | 0/3 | 0 | 0 | 0 | ||||||
| 10 | 4/4 | 4.5 | 5.2 | 4.3 | 5.3 | 0/3 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | |||||
| 12 | 3/3 | 3.9 | 4.4 | 3.7 | 0/3 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||||
| 14 | 4/4 | 3.8 | 3.7 | 3.5 | 3.8 | 0/4 | 0 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||
| Aedes aegypti titers post-IT inoculation. | ||||||||||||||||||
| 0 | 2/5 | 2.4 | 0 | 0 | 0 | 2.4 | 0/5 | 0 | 0 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||
| 1 | 3/3 | 2.7 | 4.3 | 4.3 | 0/3 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||||
| 2 | 3/3 | 4.4 | 4.6 | 5.1 | 0/3 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||||
| 4 | 3/3 | 3.4 | 4.4 | 4.5 | 0/3 | 0 | 0 | 0 | 0/3 | 0 | 0 | 0 | ||||||
| 8 | 3/3 | 5.3 | 3.8 | 4.1 | 1/3 | 2.2 | 0 | 0 | 1/3 | 0 | 1.4 | 0 | ||||||
| 10 | 3/3 | 3.7 | 3.8 | 3.7 | 1/3 | 0 | 0 | 2.2 | 1/3 | 1.6 | 0 | 0 | ||||||
| 12 | 3/3 | 3.5 | 3.4 | 4.3 | 1/3 | 2.1 | 0 | 0 | 1/3 | 0 | 1.7 | 0 | ||||||
| 14 | 2/2 | 3.4 | 3.4 | 0/5 | 0 | 0 | 0 | 0 | 0 | 1/3 | 1.1 | 0 | 0 | |||||
†
Three-to-five mosquitoes were harvested at each timepoint, represented by specimens A-E.
††
Zeros indicate below LOD and not necessarily negative.