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. Author manuscript; available in PMC: 2018 Apr 10.
Published in final edited form as: Top Magn Reson Imaging. 2016 Oct;25(5):215–221. doi: 10.1097/RMR.0000000000000098

Figure 6.

Figure 6

(A) In vivo 19F MRS demonstrated efficient conversion of prodrug 5-FC to 5-FU and its metabolites F-Nucl by nanoplex localized in MB-MDA-231 tumor. 5-FC was injected at 24 h after nanoplex injection. Adapted with permission from 14. (B) In vivo 19F MR spectra acquired from a PC3-PIP tumor at 24 and 48 h after i.v. injection of the PSMA-targeted nanoplex carrying bCD and siRNA-Chk. Spectra were acquired after a combined i.v. and i.p. injection of 5-FC.18a (C) Representative in vivo tCho maps and color-coded tCho intensity acquired in MB-MDA-231 tumor 14. (D) In vivo tCho density maps from 2DCSI data sets acquired from a representative PC3-PIP tumor before and 48 h after i.v. injection of the PSMA-targeted nanoplex. Corresponding in vivo tCho maps from the same 2D CSI data sets. Representative one voxel spectra from the same 2D CSI (D) tCho concentration calculated in arbitrary units before and at 48 h after injection of the nanoplex. Adapted with permission from 18a.