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. 2018 Mar 27;9(23):16311–16329. doi: 10.18632/oncotarget.24632

Figure 2. Distinctive features of the vascular and immune stroma of the four models of experimental malignant mesotheliomas.

Figure 2

Immunohistochemical evaluation of blood vessels density and size (vWf: von Willebrand factor), and of the macrophagic (ED1) and T-lymphocytic (CD3 and CD8) infiltration of the tumor stroma. The four models displayed distinctive characteristics: the M5-T2 tumors display a moderate blood vessel density (arrowheads) and a low T lymphocytic and macrophagic infiltration of the stroma (very low number of immunopositive cells on the ED1, CD3 and CD8 pictures); the F4-T2 and F5-T1 neoplasms are characterized by a moderate angiogenic activity (arrowheads) and a marked to severe infiltration of the tumor stroma by macrophages and particularly CD3+ T-lymphocytes, including CD8+ T-cells (asterisks: high number of immunopositive cells on the ED1, CD3 and CD8 pictures); the M5-T1 tumors are characterized by a high vascular density (arrowheads) and a low T lymphocytes and macrophages infiltration, particularly of the center of the nodules, with immune cells mostly located at the periphery of the neoplastic tissue (low number of immunopositive cells on the ED1, CD3 and CD8 pictures).