Table 2. Histological and immunohistochemical features of cancer and stromal cell interactions.

	Histological type*	Infiltration	Atypia	Mean Ki67 index per 10 HPF	Blood vessel density	CD3+ T-cell count (tumor periphery) per HPF	CD3+ T-cell count (tumor center) per HPF	CD8+ T-cell count (tumor periphery) per HPF	CD8+ T-cell count (tumor center) per HPF	ED1+ macrophages (tumor periphery) per HPF	ED1+ macrophages (tumor center) per HPF
M5-T2	Sarcomatoid	-	+/-	56	+/-	36	96	48	82	20	36
	Sarcomatoid	-	+/-	61	+/-	28	82	18	48	10	32
	Mean			58.5		32.0	89.0	33.0	65.0	15.0	34.0
F4-T2	Mixed, mainly sarcomatoid	+/-	+	248	+	88	62	64	56	64	22
	Sarcomatoid	+/-	+/-	164	+	92	132	88	62	32	110
	Sarcomatoid	+/-	+	148	+	98	56	110	64	48	88
	Mean			186.7		92,7	83.3	87.3	60.7	48.0	73.3
F5-T1	Sarcomatoid	+	+	180	+/-	46	88	46	52	52	96
	Mixed, mainly sarcomatoid	+	++	220	+	32	44	12	56	28	82
	Sarcomatoid	+	+	186	+	28	56	14	36	62	52
	Mixed, mainly sarcomatoid	++	+	228	+	36	46	28	30	30	18
	Mean			203.5		35.5	58.5	25.0	43.5	43.0	62.0
M5-T1	Mixed, mainly sarcomatoid	++	++	125	+	42	58	34	38	20	54
	Sarcomatoid	+	++	110	+	54	32	28	14	32	40
	Sarcomatoid	++	+	158	++	42	10	36	12	18	44
	Mixed, mainly sarcomatoid	++	+	172	++	82	30	24	20	16	10
	Sarcomatoid	+	++	146	+	62	18	40	16	24	22
	Sarcomatoid	++	++	142	+	36	12	36	18	48	24
	Sarcomatoid	++	+	160	++	96	16	58	18	18	16
	Sarcomatoid	++	+	130	++	16	20	62	22	26	32
	Sarcomatoid	++	+	108	++	86	22	48	14	22	10
	Mean			139.0		57.3	24.2	40.6	19.1	24.0	26.5

^*For invasive tumors, the different situations analyzed corresponded to multiple metastatic localizations.