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. 2018 Mar 27;9(23):16489–16500. doi: 10.18632/oncotarget.24740

Figure 5. The glucosyltransferase domain of TpeL is transported effectively via PA into Panc-1 but not into Capan-2 cells.

Figure 5

(A) LFN-TpeL inhibits the Ras pathway in Panc-1 cells. Cells were intoxicated for 6 h with the indicated concentrations of LFN-TpeL and a fixed concentration of PA (10 nM). (B) The Western blot is a representative of three independent experiments. LFN-TpeL inhibits proliferation of Panc-1 cells. Cells were intoxicated as in A. Cell proliferation was measured by the incorporation of BrdU in intoxicated cells compared to an untreated control. The figure shows the result of three independent experiments. (C) LFN-TpeL is not effective in Capan-2 cells. Cells were intoxicated for 4 h at the indicated concentrations of LFN-TpeL and a fixed concentration of PA (10 nM). The Ras downstream signaling was not altered after intoxication. Data shown are a representative of three independent experiments.