Table 1. Clinical grading of cytokine release syndrome.

Grade	Clinical symptoms / Therapy
Grade 1	Not life-threatening symptoms. Only symptomatic therapy is advised – intravenous fluids, antipyretics
Grade 2	Symptoms that require moderate intervention. Oxygen requirement <40% or arterial hypotension treated with fluids or low dose vasopressor or grade 2 organ toxicity
Grade 3	Symptoms that require aggressive intervention. Oxygen requirement >40% or arterial hypotension treated high dose vasopressors or grade 3 organ toxicity or grade 4 transaminitis
Grade 4	Life-threatening symptoms, that require ventilator support or grade 4 organ toxicity, with the exception of transaminitis
Grade 5	Death of the patient