Box. : Cost units of asthma in outpatient treatment and valuation methods.

Appointments (medical, nursing, or physiotherapy), emergency care, hospitalizations (room, ward, or intensive care), and additional examinations
Brazilian Unified Health System (SUS)	Outpatient and hospital information system of the SUS – SIA and SIH/SIGTAP/DATASUSa
Supplementary Health System (SSS)	Brazilian hierarchical classification of medical procedures (CBHPM) – version 2012b
Private system	Value informed by the patient/guardian
Medications for asthma, rhinitis, and respiratory infections
Provided by the SUS	Table of prices of medications for public purchases of the Executive Department of the National Health Surveillance Agency (ANVISA), updated in March/2012c
Funded by families	Table of prices of medications for sale with maximum price to the consumer of the Executive Department of the National Health Surveillance Agency (ANVISA), updated in March/2012c. We used the mean price of three different formulations for each drug used
Immunotherapy (vaccines for allergy)
Bottle	Acquisition value informed by the Financial Division of the Unit – April 2012
Administration (all units of the SUS)	Outpatient and hospital information system of the SUS – SIA and SIH/SIGTAP/DATASUSa
Environmental control measures
Items purchased (covers, curtains, air filters) and expenses for works on flooring, painting, and change of furniture	Value informed by the patient/guardian
Transportation to the health unit for care and exams
Public transportation or taxi	Value informed by the patient/guardian
Private vehicle or social assistance vehicles of the SUS	The cost was estimated using the value of 1 liter of gasoline for each 10 km of distance traveled The distances between the starting point and the destination were obtained from the website Google Mapsd We used the mean gas price of March/2012 provided by the National Agency of Petroleum (ANP)e
Absenteeism
School	Number of days (not valued)
Work (leaves up to 15 days)	Value of each day = informed monthly income of the individual/21 days Cost = value of each day x number of days lost
Work (Sickness benefit [ADB] leaves > 15 days)	Value of each month = informed monthly income of the individual Cost = monthly income x number of months of leaves

SUS: Brazilian unified health system; SAI: outpatient information system; SIH: hospital information system; SIGTAP: management system of the table of procedures, medicines, and OPM (orthotics, prosthetics, and materials) of the SUS; DATASUS: information technology department of the SUS; SSS: supplementary health system; CBHPM: Brazilian hierarchical classification of medical procedures

^a Table of procedures - outpatient and hospitalization SIA and SIH – SUS; 2014 [cited 2017 Dec 1]. Available from: http://sigtap.datasus.gov.br/tabela-unificada/app/sec/inicio.jsp

^b Brazilian hierarchical classification of medical procedures (CBHPM); 2012 [cited 2014 Oct 21]. Available from: http://www.acm.org.br/cbhpm-2012/

^c National Health Surveillance Agency (ANVISA - BR). Brasília (DF), Brazil. Table of prices of medications for public purchases of the Executive Department of ANVISA; 2012 [cited 2014 Oct 21]. Available from: http://portal.anvisa.gov.br/cmed

^d Google. Google Maps. Distances in KM between the starting point (residence of the patient) and the destination (health unit); 2014 [cited 2017 Dec 1]. Available from: https://www.google.com.br/maps/place/Av.+Mal.+Rondon,+381+-+S%C3%A3o+Francisco+Xavier,+Rio+de+Janeiro+-+RJ,+20950-003/@-22.9061884,-43.2795421,13z/data=!4m5!3m4!1s0x997e7d1d6deb6f:0x43bf435b497372f9!8m2!3d-22.9061884!4d-43.2445232

^e National Agency of Petroleum, Natural Gas, and Biofuels (ANP - BR) – Rio de Janeiro (RJ), Brazil; 2012 [cited 2017 Dec 1]. Historical series of the surveys of fuel prices and sales margins. Available from: http://anp.gov.br/wwwanp/precos-e-defesa-da-concorrencia/precos/levantamento-de-precos/serie-historica-do-levantamento-de-precos-e-de-margens-de-comercializacao-de-combustiveis