. Author manuscript; available in PMC: 2019 Mar 9.

Published in final edited form as: ACS Infect Dis. 2018 Jan 8;4(3):349–359. doi: 10.1021/acsinfecdis.7b00122

Table 1.

Screening statistics

Total HTS compounds screened	1,814,611
Predicted hit rate, %^a	0.14
Predicted 3SD cutoff, %^a	15.10
No. primary 1536 assay plates	1376
Average Z′ (SD)	0.72 (0.03)
Average robust 3SD cutoff, %	15.95
Average hit rate, %	0.31
Number robust actives in primary screen	5544
Statistical actives upon replicate screening	396
Potency bins (pIC₅₀) earmarked compounds
< 5	125
5 – 6	17
6 – 7	2
>7	0

Based on data obtained in the validation set (see Table S1)