Table 3.
Patient baseline characteristics
| Parameter | Placebo group n=26 | CD133+ group n=21 | MNC group n=30 | P value |
|---|---|---|---|---|
| Age (Y), mean (SD) | 55.50 (8.54) | 53.14 (8.56) | 51.45 (7.49) | NS |
| Females, n (%) | 3 (11.5) | 2 (9.5) | 3 (10) | NS |
| Body mass index, mean (SD) | 26.7 (4.2) | 27.9 (2.6) | 26.0 (2.7) | NS |
| Duration*, (median days) | 32.5 | 30 | 26.5 | NS |
| Min-Max (day) | 10-79 | 10-90 | 10-76 | |
| CAD, n (%) | 0.039 | |||
| LAD only | 2 (7.6) | 0.0 | 5 (16.6) | |
| LAD+RCA/LCX | 4 (15.3) | 6 (28.5) | 11 (36.6) | |
| LAD+RCA+LCX | 20 (76.9) | 15 (71.4) | 14 (46.6) | |
| Diabetes mellitus, n (%) | 10 (38.4) | 6 (28.5) | 11 (36.6) | NS |
| Hypertension, n (%) | 6 (23.0) | 7 (33.3) | 6 (20.0) | NS |
| Hyperlipidemia, n (%) | 14 (53.8) | 9 (42.8) | 15 (50.0) | NS |
| Smoking, n (%) | 12 (46.1) | 7 (33.3) | 15 (50.0) | NS |
| Preoperative medication, n | NS | |||
| Aspirin | 22 | 16 | 24 | |
| Clopidogrel | 13 | 11 | 16 | |
| Βeta-blockers | 24 | 16 | 23 | |
| ACE inhibitors | 13 | 12 | 20 | |
| Statins | 22 | 18 | 21 | |
| Nitrates | 20 | 14 | 8 | |
| Diuretic | 10 | 6 | 8 | |
| Digoxin | 9 | 8 | 7 | |
| Thrombolytic | 12 | 10 | 14 | |
| Lab test (U/L) [mean (SD)] | NS | |||
| Peak CK-total | 774 (541) | 924 (301) | 646 (310) | |
| Peak CK-MB | 52 (37) | 54 (24) | 76 (74) | |
| SPECT [mean (SD)] | NS | |||
| LVEF (%) | 40.47 (15.12) | 39.80 (10.63) | 37.06 (9.01) | |
| PDS | 10.82 (9.24) | 17.10 (10.25) | 16.38 (9.98) | |
| NV | 2.05 (3.12) | 4.14 (3.65) | 3.00 (3.31) | |
| WMS | 5.11 (3.62) | 5.50 (3.74) | 6.93 (5.00) | |
| Dec. Thickening | 8.64 (6.86) | 11.10 (4.25) | 14.46 (8.55) | |
| S. echo, mean (SD) | ||||
| LVEF (%) | 32.90 (8.40) | 31.13 (5.37) | 32.34 (5.86) | NS |
| NV | 5.83 (0.77) | 5.96 (0.75) | 6.32 (0.68) | NS |
| WMSI | 2.00 (0.09) | 2.14 (0.11) | 1.96 (0.07) | NS |
| LVEDD (mm) | 55.60 (6.37) | 59.19 (7.03) | 53.08 (5.36) | 0.012 |
| LVESD (mm) | 43.98 (8.50) | 46.65 (7.78) | 40.68 (6.36) | 0.050 |
| Operative details | NS | |||
| Number of grafts, mean (SD) | 3.6 (0.7) | 3.5 (0.8) | 3.2 (0.8) | |
| Lima grafts, n | 26 | 20 | 30 | |
| X-clamp time (minute) | 39 (10) | 46 (16) | 45 (13) | |
| Perfusion time (minute) | 68 (18) | 74 (27) | 73 (21) | |
MNC; Mononuclear cells, CAD; Coronary artery disease, LAD; Left anterior descending, RCA; Right coronary artery, LCX; Left circumflex artery, SPECT; Single photon emission computed tomography, LVEF; Left ventricular ejection fraction, PDS; Perfusion defect score, NV; Non-viable segments, WMS; Wall motion score, Dec. Thickening; Decreased systolic wall thickening, S. echo; Stress echocardiography, WMSI; Wall motion score index, LVEDD; Left ventricular end diastolic diameter, LVESD; Left ventricular end systolic diameter, NS; Not significant, *; Days from myocardial infarction (MI) to coronary artery bypass graft (CABG).