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. Author manuscript; available in PMC: 2018 Apr 10.
Published in final edited form as: Neuron. 2017 Aug 31;95(6):1319–1333.e5. doi: 10.1016/j.neuron.2017.08.023

Figure 8. Model of the Mechanisms Involved in Neurotransmitter Respecification Affecting Social Preference.

Figure 8

Kinship raising conditions provide olfactory cues that determine behavioral attraction or aversion toward siblings and non-siblings. These cues can also affect social preference. Sustained kin (sibling condition, left) or non-kin (non-sibling condition, right) odorant exposure for 48 hr during development drives activity-dependent DA/GABA switching in neurons of the developing AOB. Signaling is regulated by miRs acting on Pax6 and Bcl11b transcripts to control DA and GABA expression that determines social preference.