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. 2017 Nov 2;32(3):1207–1221. doi: 10.1096/fj.201700444RR

Figure 1.

Figure 1.

Microtubule dynamics mediates 3D cell migration. A–F). Typical trajectories of 25 individual control HT-1080 cells and cells treated with the microtubule-depolymerizing drug nocadozole and the microtubule-stabilizing drug taxol, migrating on collagen I–coated 2D substrates and inside 3D collagen I matrices. G, H). Population-averaged MSDs of control cells and cells treated with nocodazole (G) or taxol (H) migrating on 2D substrates. I, J). Population-averaged MSDs of control cells and cells treated with nocodazole (I) or taxol (J) migrating inside 3D collagen I matrix. K–N). MSDs of nocodazole- and taxol-treated cells migrating on 2D substrates (K, M) and in 3D matrix (L, M) evaluated at time scales of 1 h. For each condition, n = 3 biologic repeats; at least 60 cells were probed. *P < 0.05, **P < 0.01, ***P < 0.001.