Fig. 1.

Structure of Brugia malayi venom allergen-like protein 1 (BmVAL-1). (A) Cartoon of a monomer of BmVAL-1 in rainbow colours from N-ter (blue) to C-ter (red). The two longest helices, α 1 and α3, that form the palmitate cavity and the caveolin binding motif loop (CBM) are indicated, while glycans are shown as sticks. Also shown are the histidines that coordinate divalent cations in the central cavity. (B) Channels generated with CAVER 3.0 (in gray) link all major cavities (shown as gray bubbles) on a monomer of BmVAL-1. (C) Superposition of Necator americanus Ancylostoma secreted protein-2 (Na-ASP-2), and pathogen-related yeast protein 1 (Pry1) with BmVAL-1 (shown as aquamarine cartoons) and the channels and cavities generated from BmVAL-1 with CAVER 3.0. B and C are shown in same view as A.