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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: J Immunol. 2018 Mar 12;200(8):2941–2956. doi: 10.4049/jimmunol.1701658

Fig. 8. Conservation of PID-associated disease modules were detected in the mRNA transcript profiles of women with CT-induced subclinical PID.

Fig. 8

(A) Zsummary statistic was computed for each module as an overall measure of its preservation with regards to density and connectivity. Circles, (colors corresponding with the previously characterized co-expression modules identified via WGCNA) denote Zsummary preservation scores. A Zsummary score < 2 indicates no preservation, a score > 10 (green dotted line) indicates strong preservation and scores of 2-10 indicate weak to moderate evidence of preservation. Observed (B) and permuted (C) scatterplots of differences in connectivity, DiffK vs. expression level, t statistic, for transcriptional responses of women with subclinical PID associated with CT infection compared to women with cervical STI and and normal histology. p = 0.01 for sector 2; p = 0.02 for sector 3; p = 0.04 for sector 5; and p = 0.02 for sector 6. All other sectors were not significant. P value derived after 1000 permutations.