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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: J Immunol. 2018 Feb 28;200(8):2535–2541. doi: 10.4049/jimmunol.1701587

Figure 1. Immunoregulatory pathway-associated proteins in exosomes derived from LTxR diagnosed with BOS and stable LTxR.

Figure 1

Exosomes isolated from the sera of LTxR with BOS show significantly higher lung-associated SAg, Col-V and Kα1T, and 20S proteasome α3 subunit in LTxR diagnosed with BOS than in stable LTxR (A, B). Exosomes isolated from BOS demonstrated presence of co-stimulatory molecules CD-80, CD-86, CD-40 and MHC class II molecules (B) Transcription factors NF-kB, HIF-1A, MHC class II transactivator, IRAK-1 and MyD88 (C) but not in the exosomes of stable LTxR. Exosomes isolated from both LTxR with BOS and stable LTxR demonstrated the presence of the cell adhesion molecules PECAM, P-selectin, VCAM, E-selectin, ICAM, and E-cadherin (D). Alix served as loading control and exosome-specific marker.