Table 2.
Hazard ratios (95% CIs) of incident VTE after AF, for overall VTE and by VTE type: The Atherosclerosis Risk in Communities Study, 1987-2011
No AF (n=13,081) | AF (n=2048) | |
---|---|---|
VTE (n = 681) | ||
# Events | 613 | 68 |
Person-years | 259,659 | 10,759 |
Incidence Rate (95% CI)* | 2.4 (2.2-2.6) | 6.3 (4.9-8.0) |
Hazard ratio (95% CI) | ||
Model 1 | 1 (REF) | 2.02 (1.56-2.61) |
Model 2 | 1 (REF) | 1.71 (1.32-2.22) |
Model 3 | 1 (REF) | 1.88 (1.44-2.45) |
PE (without DVT) (n = 190) | ||
# Events | 173 | 17 |
Incidence Rate (95% CI)* | 0.7 (0.6-0.8) | 1.6 (0.96-2.5) |
Hazard ratio (95% CI) | ||
Model 1 | 1 (REF) | 1.59 (0.96-2.64) |
Model 2 | 1 (REF) | 1.41 (0.85-2.36) |
Model 3 | 1 (REF) | 1.47 (0.86-2.52) |
Any DVT† (n = 491) | ||
# Events | 440 | 51 |
Incidence Rate (95% CI)* | 1.7 (1.5-1.9) | 4.7 (3.6-6.2) |
Hazard ratio (95% CI) | ||
Model 1 | 1 (REF) | 2.23 (1.65-3.00) |
Model 2 | 1 (REF) | 1.86 (1.37-2.51) |
Model 3 | 1 (REF) | 2.07 (1.52-2.81) |
Incidence rate is per 1000 person-years.
Includes events presenting as DVT alone, and those presenting as both DVT and PE.
CI, confidence interval; VTE, venous thromboembolism; AF, atrial fibrillation; DVT, deep vein thrombosis.
Model 1 is adjusted for age, sex and race-field center.
Model 2: Model 1+ income, education, physical activity, smoking, waist circumference, height, systolic blood pressure, anti-hypertensive medication, diabetes, prevalent coronary heart disease, prevalent heart failure, prevalent anticoagulant use and eGFR.
Model 3: Model 2 + time-dependent anticoagulant use.