Table 4.
Hazard ratios (95% CI) of incident AF after VTE, overall and by type of VTE: The Atherosclerosis Risk in Communities Study, 1987-2011
| No VTE (n=14,516) | VTE (n=613) | |
|---|---|---|
| # AF Events | 2,048 | 62 |
| Person-years | 279,785 | 2,990 |
| Incidence Rate (95% CI)* | 7.3 (7.0-7.6) | 20.7 (16.0-26.4) |
| Hazard ratio (95% CI) | ||
| Model 1 | 1 (REF) | 1.94 (1.50-2.50) |
| Model 2 | 1 (REF) | 1.73 (1.34-2.24) |
| Model 3 | 1 (REF) | 1.20 (0.91-1.57) |
| No VTE (n=14,858) | Any PE† (n=271) | |
| # AF Events | 2,090 | 20 |
| Incidence Rate (95% CI)* | 7.4 (7.1-7.7) | 16.4 (10.4-24.9) |
| Hazard ratio (95% CI) | ||
| Model 1 | 1 (REF) | 1.44 (0.93-2.24) |
| Model 2 | 1 (REF) | 1.29 (0.83-2.01) |
| Model 3 | 1 (REF) | 0.73 (0.46-1.16) |
| No VTE (n=14,787) | DVT only (n=342) | |
| # AF Events | 2,068 | 42 |
| Incidence Rate (95% CI)* | 7.4 (7.0-7.7) | 23.7 (17.3-31.7) |
| Hazard ratio (95% CI) | ||
| Model 1 | 1 (REF) | 2.28 (1.68-3.10) |
| Model 2 | 1 (REF) | 2.05 (1.50-2.78) |
| Model 3 | 1 (REF) | 1.61 (1.18-2.21) |
*
Incidence rate is per 1000 person-years.
†
Includes events presenting as PE alone, and those presenting as both DVT and PE.
CI, confidence interval; AF, atrial fibrillation; VTE, venous thromboembolism.
Model 1 is adjusted for age, sex and race-field center.
Model 2: Model 1+ income, education, physical activity, smoking, waist circumference, height, systolic blood pressure, anti-hypertensive medication, diabetes, prevalent coronary heart disease, prevalent heart failure, prevalent anticoagulant use and eGFR.
Model 3: Model 2 + time-dependent anticoagulant use.