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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: J Immunol. 2018 Mar 14;200(8):2748–2756. doi: 10.4049/jimmunol.1701492

Figure 3. STING-dependent IFN production is necessary but not sufficient to induce necroptosis.

Figure 3

(A) Kinetic cell death of WT or Ifnar1−/− BMDM after treatment with 2 μg/ml cytosolic DNA and 50 μM pan-caspase inhibitor zVAD. (B) Kinetic cell death of WT or Ifnar1−/− BMDM after treatment with 2 μg/ml cGAMP and 25 μM pan-caspase inhibitor zVAD. (C) Kinetic cell death of WT or Ripk3−/− BMDM after treatment with 100 units/ml recombinant IFN and 25 μM pan-caspase inhibitor zVAD.