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. Author manuscript; available in PMC: 2019 Apr 15.
Published in final edited form as: J Immunol. 2018 Mar 14;200(8):2748–2756. doi: 10.4049/jimmunol.1701492

Figure 6. STING agonists induce sterile shock that engages TNF, IFN, and necroptosis in vivo.

Figure 6

(A) Survival analysis and serum IL-6 of age/sex matched WT C57BL/6J and Tmem173−/− mice after intraperitoneal injection of 40 mg/kg DMXAA. Serum was collected 6 hours post treatment. (B) Survival analysis and serum IL-6 of age/sex matched WT C57BL/6J, Tnf−/−, and Ifnar1−/− mice after intraperitoneal injection of 40 mg/kg DMXAA. (C) Survival analysis and serum IL-6 of age/sex matched WT C57BL/6J and Mlkl−/− mice after intraperitoneal injection of 40 mg/kg DMXAA. (D) Survival analysis and serum IL-6 of littermate C57BL/6N Ripk3+/+, Ripk3+/−, Ripk3−/− mice after intraperitoneal injection of 40 mg/kg DMXAA. *p < 0.05, **p < 0.01, ***p < 0.001. All data is pooled from three or more independent experiments. B6/J WT data is pooled from all experiments and separated to different panels for ease of data comparison within panel.