Table 3.
Hazard ratio (HR) of lung cancer by histological subtype in relation to relative telomere length The Singapore Chinese Health Study 1993–2015
| Relative telomere length in quintile | Person-years | Adenocarcinoma | Squamous cell cancer | Cancer of other/unknown histology | |||
|---|---|---|---|---|---|---|---|
|
|
|
|
|||||
| No | HR (95% CI)* | No | HR (95% CI)* | No | HR (95% CI)* | ||
| All subjects | |||||||
| 1st (shortest) | 59,803 | 44 | 1.00 | 28 | 1.00 | 72 | 1.00 |
| 2nd | 62,041 | 50 | 1.29 (0.86, 1.94) | 32 | 1.43 (0.86, 2.37) | 56 | 0.96 (0.68, 1.37) |
| 3rd | 63,019 | 63 | 1.75 (1.18, 2.57) | 19 | 0.96 (0.53, 1.73) | 51 | 1.01 (0.71, 1.45) |
| 4th | 63,989 | 48 | 1.51 (1.00, 2.29) | 18 | 1.11 (0.61, 2.02) | 37 | 0.89 (0.59, 1.33) |
| 5th (longest) | 65,355 | 83 | 2.84 (1.94, 4.15) | 16 | 1.13 (0.60, 2.13) | 37 | 1.05 (0.69, 1.58) |
| P trend | <0.0001 | 0.9886 | 0.9714 | ||||
*
Adjusted for age, sex, dialect group, education, body mass index, number of cigarettes per day, and number of years of smoking, number of years since quitting smoking (for former smokers only), and alcohol consumption.