. Author manuscript; available in PMC: 2019 Jun 1.

Published in final edited form as: Int J Cancer. 2018 Jan 25;142(11):2234–2243. doi: 10.1002/ijc.31251

Table 4.

Hazard ratio (HR) of lung adenocarcinoma in relation to relative telomere length by smoking status, gender and duration of follow-up The Singapore Chinese Health Study 1993–2015

Relative telomere length in quintile	Person-years	No. of adenocarcinoma	HR (95% CI)^*	P for trend
Never smokers
1^st (shortest)	37,950	18	1.00	<0.0001
2^nd	42,057	21	1.22 (0.65, 2.29)
3^rd	44,479	26	1.53 (0.84, 2.81)
4^th	47,059	23	1.39 (0.74, 2.60)
5^th (longest)	49,727	50	3.14 (1.80, 5.49)
Ever smokers
1^st (shortest)	21,854	26	1.00	0.0010
2^nd	19,984	29	1.37 (0.80, 2.32)
3^rd	18,540	37	1.93 (1.16, 3.20)
4^th	16,930	25	1.63 (0.93, 2.85)
5^th (longest)	15,628	33	2.46 (1.45, 4.18)
Males
1^st (shortest)	31,406	34	1.00	0.0003
2^nd	29,425	29	1.04 (0.63, 1.70)
3^rd	27,902	39	1.55 (0.97, 2.47)
4^th	25,261	28	1.39 (0.83, 2.30)
5^th (longest)	23,602	41	2.33 (1.46, 3.74)
Females
1^st (shortest)	28,397	10	1.00	<0.0001
2^nd	32,616	21	2.09 (0.98, 4.44)
3^rd	35,117	24	2.37 (1.13, 4.96)
4^th	38,728	20	1.99 (0.93, 4.29)
5^th (longest)	41,753	42	4.26 (2.11, 8.61)
<5 years of follow-up
1^st (shortest)	25,007	10	1.00	0.0002
2^nd	25,399	14	1.64 (0.73, 3.69)
3^rd	25,478	18	2.37 (1.09, 5.16)
4^th	25,561	13	2.00 (0.87, 4.62)
5^th (longest)	25,611	24	4.19 (1.96, 8.96)
≥5 years of follow-up
1^st (shortest)	34,796	34	1.00	0.0001
2^nd	36,641	36	1.19 (0.74, 1.90)
3^rd	37,541	45	1.56 (1.00, 2.45)
4^th	38,428	35	1.36 (0.84, 2.20)
5^th (longest)	39,744	59	2.46 (1.59, 3.82)

Adjusted for age, sex, dialect group, education, body mass index, number of cigarettes per day, and number of years of smoking, number of years since quitting smoking (for former smokers only), and alcohol consumption.