TABLE 2.
Immunohistochemical and Molecular Findings in Six Cases of NUT-Associated Tumor of Soft Tissue and Viscera.
| Pt | panCK | HMWK | LMWK | C-4 | p63 | S100 | GFAP | Syna | Chro | Actin | Desmin | CD34 | NUT | Molecular |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | 5+ | 5+ | 5+ | 1+ | 2+ | − | 5+ | 2+(w) | − | − | − | − | 5+ | BRD3-NUTM1 |
| 2 | − | − | − | − | − | − | − | − | − | 1+(w) | − | − | − | BCORL1-NUTM1 |
| 3 | 2+(w) | − | 2+(w) | − | − | − | 3+(w) | − | − | − | − | − | − | MXD1-NUTM1 |
| 4 | − | − | − | − | − | N/A | 2+ | 1+ | − | N/A | N/A | N/A | 5+ | BRD4-NUTM1 |
| 5 | 1+(w) | − | 1+(w) | N/A | − | − | 1+(w) | − | − | − | − | 5+ | BRD4-NUTM1 | |
| 6 | 5+* | 2+ | N/A | 4+ | 1+ | N/A | N/A | − | − | N/A | − | N/A | 3+ (w) | BRD4-NUTM1 |
Abbreviations: C-4 (Claudin-4); Chro (chromogranin); HMWK (high molecular weight keratin); LMWK (low molecular weight keratin); w (weak); N/A (not assessed); panCK (pancytokeratin); Pt (Patient number); Syna (synaptophysin); − (negative)
*
diffuse strong immunoreactivity for CK7.(8)