Table 3.
Antibacterial activity of disulfides 1 against Gram-positive and Gram-negative species.
| Gram-positive | -negative | strain | MIC (μM) | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
|
| ||||||||||
| 1a | 1c | 1g | 1h | 1i | 1j | 1o | DSF | CIP | ||
| Bacillus cereus | Gibson 971 | 1 | 1 | 1 | 2 | 1 | 1 | 2 | 4 | 0.5 |
| Corynebacterium striatum | FS-1 | >32 | >32 | 32 | 16 | 16 | 16 | 32 | >32 | >32 |
| Listeria monocytogenes | Gibson | 32 | 16 | 8 | 8 | 4 | 4 | 8 | >32 | 4 |
| Micrococcus luteus | SK58 | 32 | 16 | 16 | 16 | 16 | >32 | 16 | 32 | 4 |
| Rhodococcus erythropolis | SK121 | 16 | 16 | 16 | 8 | 16 | 16 | 16 | 16 | ≤0.5 |
|
| ||||||||||
| Acinetobacter baumannii | AB5075 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |
| Brucella neotomae | 5K33 | >32 | >32 | 32 | >32 | >32 | >32 | 32 | >32 | 1 |
| Burkholderia cepacia | UCB 717 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 4 |
| Burkholderia multivorans | CF2 | 32 | 32 | >32 | >32 | >32 | >32 | 32 | 32 | 8 |
| Citrobacter freundii | 4_7_47CFAA | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |
| Escherichia coli | DC10B | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |
| Klebsiella pneumoniae | 700603 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 2 |
| Proteus mirabilis | HM-752 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |
| Pseudomonas aeruginosa | 15442 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 1 |
| Salmonella typhi | Ty2 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |
| Shigella dysenteriae | Newcastle 1934 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 4 |
| Vibrio cholera | TS (D4) | 32 | 32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |
| Yersinia enterocolitica | WA-314 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | 2 |
| Yersinia pseudotuberculosis | P61 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | >32 | ≤0.5 |