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. Author manuscript; available in PMC: 2019 May 1.
Published in final edited form as: Bioorg Med Chem Lett. 2018 Mar 10;28(8):1298–1302. doi: 10.1016/j.bmcl.2018.03.023

Table 4.

Microsomal stability and calculated physiochemical properties.

DSF 1j
MW (g/mol) 296.5 293.6
pKaa 0.86 0.78
clogPa 3.82 6.53
PSA (Å2)a 121 85.9
rotatable bondsa 7 11
t½ (min)b 0.75 61.2
CLint (μL/min/mg protein)c 1848 22.6
a

calculated value [20,21]

b

elimination half-life in pooled rat liver microsomes

c

intrinsic body clearance