Table 2. Association of selected microRNA ratios and 5-year survival rates in patients with early-stage non-small cell lung cancer.
| Expression level | Discovery | Validation | Combined | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Dead (N, %) |
Alive (N, %) |
HRa (95% CI) |
P | Dead (N, %) |
Alive (N, %) |
HRa (95% CI) |
P | Dead (N, %) |
Alive (N, %) |
HRa (95% CI) |
P | ||
| miR-19b/484 | Low | 9 (20.00) | 36 (80.00) | 1 | 14 (35.90) | 25 (64.10) | 1 | 23 (27.38) | 61(72.62) | 1 | |||
| High | 18 (46.15) | 21 (53.85) | 2.70 (1.06-6.89) | 3.74E-02 | 27 (61.36) | 17 (38.64) | 2.34 (1.13-4.85) | 2.15E-02 | 45 (54.22) | 38 (45.78) | 2.51 (1.45-4.34) | 9.68E-04 | |
| miR-24/142-3p | Low | 20 (35.71) | 36 (64.29) | 1 | 26 (59.09) | 18 (40.91) | 1 | 46 (46.00) | 54 (54.00) | 1 | |||
| High | 2 (9.52) | 19 (90.48) | 0.19 (0.04-0.89) | 3.48E-02 | 9 (31.03) | 20 (68.97) | 0.43 (0.19-0.98) | 4.51E-02 | 11 (22.00) | 39 (78.00) | 0.35 (0.18-0.70) | 3.07E-03 | |
| miR-27a/142-3p | Low | 19 (37.25) | 32 (62.75) | 1 | 26 (60.47) | 17 (39.53) | 1 | 45 (47.87) | 49 (52.13) | 1 | |||
| High | 3 (14.29) | 18 (85.71) | 0.25 (0.07-0.89) | 3.19E-02 | 7 (26.92) | 19 (73.08) | 0.41 (0.17-0.98) | 4.44E-02 | 10 (21.28) | 37 (78.72) | 0.38 (0.19-0.75) | 5.75E-03 | |
| miR-27a/146a | Low | 14 (26.42) | 39 (73.58) | 1 | 18 (38.30) | 29 (61.70) | 1 | 32 (32.00) | 68 (68.00) | 1 | |||
| High | 8 (42.11) | 11 (57.89) | 2.58 (1.04-6.42) | 4.14E-02 | 20 (68.97) | 9 (31.03) | 2.06 (1.06-4.03) | 3.35E-02 | 28 (58.33) | 20 (41.67) | 2.04 (1.20-3.47) | 8.31E-03 | |
| miR-27a/150 | Low | 4 (14.81) | 23 (85.19) | 1 | 6 (27.27) | 16 (72.73) | 1 | 10 (20.41) | 39 (79.59) | 1 | |||
| High | 18 (40.91) | 26 (59.09) | 3.29 (1.06-10.26) | 3.97E-02 | 31 (59.62) | 21 (40.38) | 4.13 (1.61-10.58) | 3.11E-03 | 49 (51.04) | 47 (48.96) | 3.92 (1.94-7.94) | 1.46E-04 | |
| miR-27a/339-3p | Low | 11 (24.44) | 34 (75.56) | 1 | 16 (38.10) | 26 (61.90) | 1 | 27 (31.03) | 60 (68.97) | 1 | |||
| High | 10 (50.00) | 10 (50.00) | 4.33 (1.52-12.38) | 6.17E-03 | 17 (70.83) | 7 (29.17) | 2.97 (1.32-6.66) | 8.26E-03 | 27 (61.36) | 17 (38.64) | 2.56 (1.41-4.63) | 1.93E-03 | |
| miR-27a/532-3p | Low | 11 (22.92) | 37 (77.08) | 1 (reference) | 19 (39.58) | 29 (60.42) | 1 | 30 (31.25) | 66 (68.75) | 1 | |||
| High | 10 (43.48) | 13 (56.52) | 2.92 (1.06-8.03) | 3.85E-02 | 16 (64.00) | 9 (36.00) | 2.68 (1.29-5.58) | 8.44E-03 | 26 (54.17) | 22 (45.83) | 1.94 (1.14-3.31) | 1.51E-02 | |
| miR-29a/142-3p | Low | 18 (36.73) | 31 (63.27) | 1 | 23 (57.50) | 17 (42.50) | 1 | 41 (46.07) | 48 (53.93) | 1 | |||
| High | 4 (19.05) | 17 (80.95) | 0.28 (0.09-0.92) | 3.52E-02 | 6 (25.00) | 18 (75.00) | 0.36 (0.14-0.91) | 3.12E-02 | 10 (22.22) | 35 (77.78) | 0.36 (0.18-0.74) | 5.14E-03 | |
| miR-30c/150 | Low | 9 (20.00) | 36 (80.00) | 1 | 19 (41.30) | 27 (58.70) | 1 | 28 (30.77) | 63 (69.23) | 1 | |||
| High | 10 (43.48) | 13 (56.52) | 2.74 (1.03-7.33) | 4.44E-02 | 14 (70.00) | 6 (30.00) | 2.37 (1.12-5.01) | 2.42E-02 | 24 (55.81) | 19 (44.19) | 2.55 (1.43-4.55) | 1.51E-03 | |
| miR-30c/532-3p | Low | 8 (17.78) | 37 (82.22) | 1 | 17 (39.53) | 26 (60.47) | 1 | 25 (28.41) | 63 (71.59) | 1 | |||
| High | 9 (42.86) | 12 (57.14) | 2.71 (1.03-7.17) | 4.42E-02 | 14 (63.64) | 8 (36.36) | 2.62 (1.17-5.89) | 1.94E-02 | 23 (53.49) | 20 (46.51) | 2.38 (1.28-4.44) | 6.19E-03 | |
| miR-106b/92a | Low | 10 (22.22) | 35 (77.78) | 1 | 21 (47.73) | 23 (52.27) | 1 | 31 (34.83) | 58 (65.17) | 1 | |||
| High | 9 (52.94) | 8 (47.06) | 3.23 (1.09-9.55) | 3.40E-02 | 16 (64.00) | 9 (36.00) | 2.26 (1.05-4.87) | 3.71E-02 | 25 (59.52) | 17 (40.48) | 2.91 (1.62-5.24) | 3.70E-04 | |
| miR-106b/221 | Low | 7 (20.00) | 28 (80.00) | 1 | 12 (42.86) | 16 (57.14) | 1 | 19 (30.16) | 44 (69.84) | 1 | |||
| High | 11 (45.83) | 13 (54.17) | 4.24 (1.29-13.95) | 1.74E-02 | 22 (61.11) | 14 (38.89) | 3.08 (1.28-7.42) | 1.22E-02 | 33 (55.00) | 27 (45.00) | 3.89 (1.94-7.79) | 1.32E-04 | |
| miR-106b/532-3p | Low | 9 (21.95) | 32 (78.05) | 1 | 20 (41.67) | 28 (58.33) | 1 | 29 (32.58) | 60 (67.42) | 1 | |||
| High | 10 (43.48) | 13 (56.52) | 3.21 (1.12-9.19) | 2.94E-02 | 13 (59.09) | 9 (40.91) | 2.27 (1.05-4.92) | 3.75E-02 | 23 (51.11) | 22 (48.89) | 1.86 (1.06-3.26) | 3.01E-02 | |
HR, hazard ratio; CI, confidence interval.
a
Adjusted for age, sex, smoking history, clinical stage, and treatment regimen.