Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Neurobiol Learn Mem. 2018 Feb 13;150:1–12. doi: 10.1016/j.nlm.2018.02.008

Figure 2.

Figure 2

(a) Mean (±SEM) percent test freezing 24hr after immediate shock training in rats preexposed on PD17, PD24 or PD31 using the single-exposure CPFE protocol. The CPFE was evident in animals preexposed on PD24-31 but not PD17, as reflected in higher Pre group freezing relative to Alt-Pre controls. (b) Mean (±SEM) percent expression of Egr-1 mRNA relative to homecage (HC) controls following context preexposure. Pre and Alt-Pre rats preexposed on PD24 displayed significantly elevated gene expression in all regions relative to HC controls and to rats preexposed on PD17. These increases were absent in rats preexposed on PD17. (c) Following immediate foot-shock training, Pre and Alt-Pre expression was increased similarly between PD17 and PD24 rats in all regions except the IL where PD24 expression was elevated relative to PD17 expression, and LA where only Alt-Pre exceeded HC in PD24 rats. (d) Mean (±SEM) percent expression of Egr-1 mRNA in PD31 rats following immediate foot-shock training. Learning-related increases in gene expression (Pre > Alt-Pre) in the mPFC were evident in the PL and IL but no other regions.