Deficiency of AP activity in sera of LD mice. (A) LPS-based in
vitro binding assay in sera of WT (Black, n=8), LD (Grey, n=7), and
FB−/− (White, n=4) mice. Left,
assay performed with 20% serum; Right, assay performed
with 10% serum. Samples normalized to WT 20% sera result equals
100% activity. (B) Rabbit RBC based-hemolysis assay on sera from WT
(n=14), LD (n=9), FD−/− (n=8) or
FB−/− (n=3) mice. Data normalized to WT equals
100% activity. These functional assays demonstrate a severe defect in AP
activity of LD mice.