Table 1.

Summary HIV-infected cohorts with confirmed tuberculous meningitis

Cohort	Uganda	Zimbabwe (Hakim et al.)	Brazil (Croda et al.)	Argentina (Cecchini et al.)	Vietnam (Thao et al.)*
Study Period	2011 – 2017	1994	1999–2007	1996–2004	2004–2015
N	85	21	108	101	461
Median CD4 cells/μl	81	131	65	53	39
CSF lymphocytes/mm3	75 (0–2450)	N/A	49 (0–100)	N/A	103 (0–6004)
Acellular CSF with ≤5 cells/μl	28 (33%)	5 (26%)b	20 (19%)	18 (21%)c	20 (4%)d
Normal CSF (white cells, protein, and glucose)a	3 (4%)	0 (0%)	4 (4%)	N/A	2 (0.4%)
In hospital Mortality	54%e	67%	29%	63%	N/A
9-month Mortality	N/A	N/A	41%	N/A	51%
Mortality in patients with acellular CSF	39%	N/A	55%	N/A	60%
Mortality in patients with normal CSF	0%	N/A	75%	N/A	100%

Values represent N (%) or median (range).

^*microbiologically confirmed HIV-associated TBM cases from Thao et al. Vietnam cohort included

N/A is not data available

^a“Normal CSF” defined as white cells ≤5/mm³, protein <45g/l, glucose >45mg/dl (2.5 mmol/l).

^bCSF data available for n=19.

^cCSF data available for n=91.

^dCSF data available for 458.

^eoutcome known for n=69.