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The rCAAU refolding simulation. Time 0 is the end of trajectory 8 at 300ns, at which the rCAAU tetramer was totally unfolded (no stacking in the structure, see the RMSD of trajectory 8 in Figure S25B). The rCAAU structures observed in the simulation are shown above and below the plot. Color scheme in the structure model: green, C1; blue, A2; red, A3; black, U4. At ~865 ns, the tetramer folded to A-form stacking structure.
