Table 2.

Shift from baseline in Binge Eating Scale total score severity category at week 26

Parameter	Usual Care (N = 82) n (%)	NB + CLI (N = 71) n (%)
n a	82	71
Improved		21 (29.6)
From moderate to none	5 (6.1)	14 (19.7)
From severe to none	1 (1.2)	2 (2.8)
From severe to moderate	0 (0.0)	5 (7.0)
No change	61 (74.4)	48 (67.6)
From none to none	37 (45.1)	46 (64.8)
From moderate to moderate	17 (20.7)	1 (1.4)
From severe to severe	7 (8.5)	1 (1.4)
Worsened	15 (18.3)	2 (2.8)
From none to moderate	9 (11.0)	2 (2.8)
From none to severe	2 (2.4)	0 (0.0)
From moderate to severe	4 (4.9)	0 (0.0)
P valueb		<0.0001

BES scores were categorized as follows: none = scores ≤17 indicated no significant binge eating, moderate = scores from 18 to 26 (inclusive), severe = scores ≥27 indicated severe levels of binge eating.

BES, Binge Eating Scale; CLI, comprehensive lifestyle intervention; NB, sustained release combination of naltrexone and bupropion.

^aThe number of participants with a score at both baseline and the week 26 visit. The percentages are calculated based on this n.

^bFrom a Cochran–Mantel–Haenszel test comparing shift frequencies for participants assigned to NB + CLI to those assigned to usual care, stratified by baseline BMI category.