Table 3.

Training (cohort 1) and validation (cohort 2) of univariate Cox models containing cancer stem cell marker expression or hypoxia classifiers for the endpoints loco-regional control, freedom of distant metastases and overall survival. Shown is the hazard ratio (HR) with 95% confidence interval (CI) and the p-value testing the hypothesis HR = 1.

		Loco-regional control		Distant metastases		Overall survival
		HR (95% CI)	p-Value	HR (95% CI)	p-Value	HR (95% CI)	p-Value
	Cohort
All patients
CD44 protein	1	9.09 (1.24–66.8)	0.030	2.29 (0.90–5.86)	0.084	1.78 (0.91–3.50)	0.093
	2		⁎	1.80 (0.43–7.54)	0.42	1.16 (0.53–2.53)	0.71
CD44 > 0.2	1	3.56 (1.36–9.35)	0.010	1.69 (0.83–3.43)	0.15	1.57 (0.92–2.67)	0.098
	2	2.14 (1.00–4.56)	0.049	2.30 (1.04–5.08)	0.040	1.20 (0.76–1.89)	0.44
SLC3A2 > −3.135	1	6.54 (1.97–21.7)	0.002	4.17 (1.74–10.0)	0.001	2.37 (1.36–4.13)	0.002
	2	2.45 (1.01–5.91)	0.047	1.78 (0.77–4.10)	0.18	1.19 (0.73–1.93)	0.48
MET > −4.135	1	5.19 (1.97–13.7)	0.001	3.41 (1.61–7.23)	0.001	2.74 (1.60–4.70)	<0.001
	2	1.43 (0.67–3.07)	0.35	1.18 (0.56–2.47)	0.67	0.93 (0.58–1.47)	0.74
15-gene signature	1	3.55 (1.35–9.35)	0.010	1.27 (0.65–2.46)	0.49	1.47 (0.88–2.47)	0.14
	2	2.32 (0.96–5.59)	0.061	1.06 (0.50–2.22)	0.89	1.20 (0.74–1.96)	0.46
26-gene signature	1	9.37 (2.22–39.5)	0.002	2.15 (1.01–4.55)	0.046	2.48 (1.39–4.42)	0.002
	2	3.36 (0.81–14.0)	0.097	2.16 (0.66–7.07)	0.21	1.26 (0.66–2.38)	0.48
Patients with HPV16 DNA-negative tumours
CD44 protein	1		⁎	2.20 (0.53–9.18)	0.28	1.45 (0.58–3.64)	0.43
	2		⁎	0.79 (0.19–3.35)	0.75	0.68 (0.29–1.57)	0.36
CD44 > 0.2	1	4.15 (1.25–13.8)	0.020	1.69 (0.72–3.94)	0.23	1.40 (0.76–2.58)	0.28
	2	1.85 (0.86–3.96)	0.11	2.54 (1.04–6.22)	0.041	1.17 (0.72–1.90)	0.52
SLC3A2 > −3.135	1	9.23 (1.25–68.1)	0.029	3.56 (1.08–11.7)	0.037	1.53 (0.79–2.98)	0.21
	2	1.87 (0.77–4.55)	0.17	1.80 (0.69–4.73)	0.23	1.13 (0.67–1.93)	0.64
MET > −4.135	1	3.74 (1.29–10.9)	0.015	2.82 (1.16–6.87)	0.023	2.42 (1.27–4.61)	0.007
	2	0.97 (0.45–2.08)	0.94	0.75 (0.34–1.66)	0.48	0.71 (0.43–1.16)	0.17
15-gene signature	1	4.66 (1.60–13.5)	0.005	1.54 (0.73–3.21)	0.26	1.88 (1.06–3.34)	0.031
	2	2.13 (0.88–5.15)	0.093	1.37 (0.59–3.21)	0.47	1.38 (0.80–2.37)	0.25
26-gene signature	1	11.3 (1.53–83.7)	0.017	1.51 (0.65–3.51)	0.34	2.05 (1.03–4.08)	0.040
	2	1.62 (0.39–6.78)	0.51	1.36 (0.32–5.73)	0.68	0.91 (0.42–1.99)	0.81

Bold numbers indicate significant p-Values with p < 0.05.

^⁎No convergence due to no events in the CD44 protein negative group.