Table 3.
Loco-regional control |
Distant metastases |
Overall survival |
|||||
---|---|---|---|---|---|---|---|
HR (95% CI) | p-Value | HR (95% CI) | p-Value | HR (95% CI) | p-Value | ||
Cohort | |||||||
All patients | |||||||
CD44 protein | 1 | 9.09 (1.24–66.8) | 0.030 | 2.29 (0.90–5.86) | 0.084 | 1.78 (0.91–3.50) | 0.093 |
2 | ⁎ | 1.80 (0.43–7.54) | 0.42 | 1.16 (0.53–2.53) | 0.71 | ||
CD44 > 0.2 | 1 | 3.56 (1.36–9.35) | 0.010 | 1.69 (0.83–3.43) | 0.15 | 1.57 (0.92–2.67) | 0.098 |
2 | 2.14 (1.00–4.56) | 0.049 | 2.30 (1.04–5.08) | 0.040 | 1.20 (0.76–1.89) | 0.44 | |
SLC3A2 > −3.135 | 1 | 6.54 (1.97–21.7) | 0.002 | 4.17 (1.74–10.0) | 0.001 | 2.37 (1.36–4.13) | 0.002 |
2 | 2.45 (1.01–5.91) | 0.047 | 1.78 (0.77–4.10) | 0.18 | 1.19 (0.73–1.93) | 0.48 | |
MET > −4.135 | 1 | 5.19 (1.97–13.7) | 0.001 | 3.41 (1.61–7.23) | 0.001 | 2.74 (1.60–4.70) | <0.001 |
2 | 1.43 (0.67–3.07) | 0.35 | 1.18 (0.56–2.47) | 0.67 | 0.93 (0.58–1.47) | 0.74 | |
15-gene signature | 1 | 3.55 (1.35–9.35) | 0.010 | 1.27 (0.65–2.46) | 0.49 | 1.47 (0.88–2.47) | 0.14 |
2 | 2.32 (0.96–5.59) | 0.061 | 1.06 (0.50–2.22) | 0.89 | 1.20 (0.74–1.96) | 0.46 | |
26-gene signature | 1 | 9.37 (2.22–39.5) | 0.002 | 2.15 (1.01–4.55) | 0.046 | 2.48 (1.39–4.42) | 0.002 |
2 | 3.36 (0.81–14.0) | 0.097 | 2.16 (0.66–7.07) | 0.21 | 1.26 (0.66–2.38) | 0.48 | |
Patients with HPV16 DNA-negative tumours | |||||||
CD44 protein | 1 | ⁎ | 2.20 (0.53–9.18) | 0.28 | 1.45 (0.58–3.64) | 0.43 | |
2 | ⁎ | 0.79 (0.19–3.35) | 0.75 | 0.68 (0.29–1.57) | 0.36 | ||
CD44 > 0.2 | 1 | 4.15 (1.25–13.8) | 0.020 | 1.69 (0.72–3.94) | 0.23 | 1.40 (0.76–2.58) | 0.28 |
2 | 1.85 (0.86–3.96) | 0.11 | 2.54 (1.04–6.22) | 0.041 | 1.17 (0.72–1.90) | 0.52 | |
SLC3A2 > −3.135 | 1 | 9.23 (1.25–68.1) | 0.029 | 3.56 (1.08–11.7) | 0.037 | 1.53 (0.79–2.98) | 0.21 |
2 | 1.87 (0.77–4.55) | 0.17 | 1.80 (0.69–4.73) | 0.23 | 1.13 (0.67–1.93) | 0.64 | |
MET > −4.135 | 1 | 3.74 (1.29–10.9) | 0.015 | 2.82 (1.16–6.87) | 0.023 | 2.42 (1.27–4.61) | 0.007 |
2 | 0.97 (0.45–2.08) | 0.94 | 0.75 (0.34–1.66) | 0.48 | 0.71 (0.43–1.16) | 0.17 | |
15-gene signature | 1 | 4.66 (1.60–13.5) | 0.005 | 1.54 (0.73–3.21) | 0.26 | 1.88 (1.06–3.34) | 0.031 |
2 | 2.13 (0.88–5.15) | 0.093 | 1.37 (0.59–3.21) | 0.47 | 1.38 (0.80–2.37) | 0.25 | |
26-gene signature | 1 | 11.3 (1.53–83.7) | 0.017 | 1.51 (0.65–3.51) | 0.34 | 2.05 (1.03–4.08) | 0.040 |
2 | 1.62 (0.39–6.78) | 0.51 | 1.36 (0.32–5.73) | 0.68 | 0.91 (0.42–1.99) | 0.81 |
Bold numbers indicate significant p-Values with p < 0.05.
No convergence due to no events in the CD44 protein negative group.