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. Author manuscript; available in PMC: 2018 May 15.
Published in final edited form as: Cancer Res. 2017 Sep 26;77(22):6321–6329. doi: 10.1158/0008-5472.CAN-17-1589

Figure 7. Serine biosynthesis pathway was up-regulates in HIF2α-KO-SU-R-786-o cells.

Figure 7

A, Heat map diagram of metabolites among 786-o parent cells, SU-R-786-o cells, and HIF2α-KO-SU-R-786-o cells. Precise information of all metabolites are listed in Supplementary Table 2. B, Intracellular concentration of key metabolites involved in glycolysis and serine biosynthesis pathway. Representative metabolites such as glucose 6-phosphate (G6P), 3-phosphoglycerate (3PG), 2-phosphoglycerate (2PG), pyruvate, lactate, 6-phosphogluconate (6PG), 3-Phosphoserine (3P Ser), Serine (Ser), Glycine (Gly), and Acetyl-CoA (AcCoA) are shown here. Others are listed in Supplementary Table 2.